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Phase 2 trials ran 12 weeks (METAOD005) and 24 weeks (METAOD006/OPTIONS)

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The firm detected glass particles in some vials during production, which could pose severe risks to patients

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Although this approach to handling of intercurrent events may be reflective of clinical practice, it can be a limitation for the interpretation of efficacy results given that these intercurrent events also have an effect on CV risk

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