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More than half of the tirzepatide group lost at least 20% of body weight, compared to about a quarter of the semaglutide group

Avoid magnesium oxide, which has poor absorption and less laxative effect

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After a median follow-up of 4.6 years across the full VESALIUS-CV trial, patients in the high-risk diabetes subgroup showed a 29% reduction in three-point major adverse cardiovascular events and a 21% reduction in four-point events compared with placebo the most robust cardiovascular benefit yet documented for a PCSK9 inhibitor in a population that had never had established cardiovascular disease

10.1089/ars.2012.4540 190 MittalM.SiddiquiM

Lidia Mnguez-Alarcn, a reproductive epidemiologist and assistant professor of medicine at Brigham and Women's Hospital and Harvard Medical School, noted that the research was conducted only in men with high body mass index and that the benefits may not extend to the broader population