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According to the mechanisms shown in the graphic, Retatrutide acts on: GLP-1 receptors GIP receptors Glucagon receptors By targeting all three pathways, Retatrutide supports multiple systems in the body at the same time, rather than relying on appetite suppression alone

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It paid up to $2 billion back in March 2025 for the rights to an early triple-hormone drug from a Chinese company

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