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So when you lose muscle mass, you lose thyroid power, leading to an even more sluggish metabolism

Role of Nutrition Adequate protein intake and balanced meals help support fat loss while minimizing muscle loss

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It has been observed that vitamin B12 also has antioxidant effects when it gets absorbed, and it is used as a cofactor for enzymes that are involved in the synthesis of deoxyribonucleic acid (DNA), fatty acids, and myelin

Furthermore, PNPLA2 in the heart is required to maintain the supply of FAs for cardiac function during thermogenesis, as PNPLA2 cardiac-specific deficient mice are cold intolerant (102)