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Interestingly, -tocopherol levels were not independently associated with Braak staging or neuritic plaque (NP) counts [9,12], indicating that its role may be more significant in early disease stages rather than in the progression of widespread neurodegeneration
2 Literature search strategy We conducted a comprehensive literature search to identify relevant studies on the role of riboflavin in neurological diseases
7 Systemic metabolic disorders that contribute to Alzheimer's disease 7.1 Diabetes, insulin resistance and metabolic syndrome The complex interplay of diabetes, dyslipidemia, obesity, and hypertension in clinical settings makes it challenging to pinpoint their individual roles in pathology
