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These medications work through different but related mechanismssemaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, while tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist

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Likely related to changing definitions of IC, reported prevalence rates varied substantially among early population-based studies, ranging widely from 18 to 865 women per 100,000 (0.02%0.9% prevalence