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Dangerous duet: lrrk2 and -synuclein jam at CMA

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Preclinical studies suggest these drugs modulate reward pathways, reduce cravings, and influence stress responses

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As Tschp explains, 'We realized early [on] that pharmacological targeting of just one pathway would not be sufficient to overcome the powerful drive to eat and store calories

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Mol Cell Biochem 305:23553 Koehler CM, Beverly K, Leverich EP (2006) Redox pathways in the mitochondrion

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Advanced liver disease, renal failure

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Medicare Part B does not mandate prior authorization but follows Local Coverage Determination criteria requiring documented hypogonadism diagnoses and lab-confirmed testosterone deficiency

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