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Up-regulations of hepatic HK expression [25] and muscle phosphofructokinase (PFK) of the obese rats by carnitine treatment were already demonstrated, which suggest the ability of carnitine to increase hepatic glycolysis [25] and may explain the mechanism through which they exert their roles in glucose homeostasis [26]

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[2] [5] Rybelsus is typically initiated at a low dose (3 mg once daily) and gradually increased to 7 mg or 14 mg, depending on glycaemic control and tolerability

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The drug enhances the action of GLP-1, a hormone that, apart from its role in glucose metabolism, has been shown to have protective effects on kidney cells

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