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This inhibition was evidenced by Oil Red O and AdipoRed staining, and by the downregulation of key adipogenic markers, including peroxisome proliferator-activated receptor gamma ( PPAR ), lipoprotein lipase ( LPL ), fatty acid-binding protein 4 ( FABP4 ), and CCAAT/enhancer-binding protein alpha ( C/EBP ) [12, 13, 22, 23]

doi: 10.3390/ijms232113470 229 ElyadaEBolisettyMLaisePFlynnWFCourtoisETBurkhartRAet al

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Inflammatory activation serves a notable role in this process, as M1 macrophage infiltration and the release of pro-inflammatory cytokines, such as TNF-, IL-1 and IL-6, accelerate ECM degradation and promote cell death (38)