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The ascitic fluid contains growth factors secreted by both cancer and stromal cells 9 and these factors are mitogenic to cancer cells, contributing for an ideal microenvironment for tumour growth 10,11

Research examining lasting neuroplastic changes rather than acute cognitive effects has successfully employed administration frequencies as low as three times weekly (every other day or Monday/Wednesday/Friday patterns) with outcomes comparable to daily dosing

The limited controlled trial data showed modest effects at best, which is a long way from establishing clinical usefulness

Soreness duration

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Many patients have yet to reach higher doses of the drug, and their experiences vary