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Studied for activation of 3-adrenergic signaling in adipocytes, raising intracellular cAMP and stimulating hormone-sensitive lipase to drive triglyceride breakdown

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Because it competes at the nicotinamide substrate site rather than the SAM cofactor site, it is also used as the substrate-competitive reference compound against which bisubstrate and covalent NNMT inhibitors are benchmarked

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One reviewer described severe symptoms including vomiting and headache after taking a single capsule