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When activated, the mast cells in the skin release mediators (histamines, tryptase, TNF-alpha, CXCL9, etc.) that cause inflammation, flushing, itching, or burning.[ref] Related article: Rosacea, underlying causes, genetic susceptibility Dermatographism and mast cell activation syndrome: In a survey of mast cell activation syndrome, dermatographism was found in 89% of the patients.[ref] Dermatographism is when you get welts or raised red lines when you scratch your skin lightly

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Microbiology 152:29192930

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A previous in vitro study immersed the rat tail tendon in AGEs and found that the tendon texture became stiff and rigid, and the color of the Achilles tendon was changed from pearl white to gray-yellow or gray-white [42]

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