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When the microneedle patch loaded with nano-drugs is applied to the skin, it first breaks through the stratum corneum barrier through physical puncture, rapidly dissolves and releases the encapsulated nanoparticles in the dermis [177]

Raval PM et al

The peptide preserves mitochondrial integrity by protecting against superoxide radical accumulation in mitochondrial compartments, maintaining efficient energy production and preventing mitochondrial-derived oxidative stress