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Researchers who use this product on a multi-dose schedule drawing from the same vial over days or weeks are operating without the bacteriostatic protection the product label claims to provide

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The Hsp70 homologue Lhs1p is involved in a novel function of the yeast endoplasmic reticulum, refolding and stabilization of heat-denatured protein aggregates

However, extrapolating rodent pharmacodynamics to human clinical outcomes requires extreme caution

It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question