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Diets high in UPFs may trigger both peripheral and central inflammatory responses, resulting in elevated triglyceride and TNF- levels in the liver, as well as increased IL-6 concentrations in the prefrontal cortex, as observed in animal models (116, 117) (Figure 10)

The 17.1% weight reduction seen with cagrilintide + semaglutide suggests non-overlapping receptor activity

Rotate sites each day to reduce irritation and lumps

Secondary outcomes included bioavailable testosterone, sex hormone-binding globulin (SHBG), and HbA1c levels, all assessed before and after GLP-1 treatment

Standardized tissue injuries were introduced, and comparative outcomes were assessed over a defined observation period