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Its a choice that reflects a deliberate strategy to achieve a specific pharmacokinetic profile suitable for studying the slow, steady processes of metabolism

N-Acetyl-l-cysteine exacerbates generation of IL-10 in cells stimulated with endotoxin in vitro and produces antipyresis via IL-10 dependent pathway in vivo

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But it also produces a more complex side effect profile, particularly in the first 24 to 48 hours post-injection during dose escalation phases

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