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Gpx5 is an important antioxidant enzyme involved in the regulation of oxidative stress in the epididymis and plays key roles in the storage, maturation, and transport of sperm cells

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10.1210/en.2006-0088 51 EisenbergT.KnauerH.SchauerA.BttnerS.RuckenstuhlC.Carmona-GutierrezD.et al (2009)

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It is reported that metformin decreases hyperglycemia lethality and serious problems caused by diabetes in obese patients by 30% compared to peptides like insulin and hypoglycemic agents such as glibenclamide and chlorpropamide