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The obesity drug pipeline remains robust, with next-generation therapies and novel mechanisms progressing through multiple phases of clinical development

Given multiple publications documenting a nuclear PDC 1518 , we investigated the localization of PDH in the HCC cells

10.1002/hep4.1925 23 ClemensD

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This enzymatic reaction consumes both nicotinamide and SAM, leading to depletion of NAD+ storesa critical coenzyme required for cellular energy production, DNA repair, and metabolic regulation