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Receptor binding affinity differs between the medications, with tirzepatide showing balanced activation of both receptor types at therapeutic doses

Research on GLP-1/estrogen conjugate molecules, where GLP-1 and estrogen are chemically linked, shows even more dramatic effects

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They used propensity-score matching to establish two cohorts, one with 4,807 patients who used GLP-1 medications and another with 4,807 patients who did not use GLP-1s