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4749 Glycemic control A1c reductions resulting from treatment with SGLT2-I with or without background therapy of MET in randomized trials are summarized in Table 2

If a second drug-induced liver injury signal emerges post-marketing on any approved small-molecule GLP-1, the regulatory and commercial framework will recalibrate sharply

It should be equally recognizable that this multiplicity of actions requires immense diversity of the GLP-1 signal

Ozempic and Wegovy are once-weekly subcutaneous injections , while Rybelsus is taken orally once daily

This is evidenced by up-regulation of glycolytic enzyme expression, increased rates of glucose uptake and consumption, as well as augmented ATP content, insulin secretion and glycolytic flux after removal of Exendin-4

1 Detailed results from both trials will be presented at future medical meetings and published in peer-reviewed journals