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Outcome information was collected by identifying all fracture-related diagnoses from index data onwards

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Tirzepatide is an FDA-approved prescription medication marketed as Mounjaro for type 2 diabetes mellitus and Zepbound for chronic weight management in adults with BMI 30 kg/m, or 27 kg/m with at least one weight-related comorbidity

GLP-1S binds with high affinity to the GLP-1 receptor (GLP-1R, a class B G-protein-coupled receptor) and acts as an agonist in preclinical models