So, in vitro cultures of mouse mGLUTag L cells (37, 38) and mouse assays (38) revealed that palmitate is a key factor affecting L cells as well as eliminating GLP-1 secretion rhythms, even at non-obesogenic doses, interfering with CLOCK : BMAL1 transcriptional activity, increasing Bmal1 transcriptional repression
The newer GLP-1 medications basically work by suppressing appetite and managing blood sugar levels
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Wang X, Sarkar DP, Mani P, Steer CJ, Chen Y, Guha C, et al
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