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Several studies have shown that, in addition to alterations in dopaminergic and cholinergic transmission (82), the 5-HTergic system may also be a key factor primarily linked to negative symptoms in schizophrenia (21)

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Where tirzepatide is prescribed it is available only under a physicians supervision in jurisdictions where it has been approved (Mounjaro for T2D

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Cohort 3 (from March 2027): further expansion of eligibility, with the full criteria gradually widening over the following years