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Their high water content and limited ability to penetrate certain biological barriers, such as the skin, may also restrict their application [96]

Prescription GLP-1 receptor agonists undergo rigorous testing for safety and efficacy, while most over-the-counter supplements lack the same level of scientific validation and regulation

J Pharmacol Exp Ther 2004

These studies indicate that the amount of WL may vary in real-world data compared to clinical trials [66]

doi: 10.1159/000090314