For retatrutide, published descriptions characterise it as a triple agonist engaging GLP-1, GIP, and glucagon receptors
Iqbal N, Seshadri P, Stern L, et al
Substantial weight regain after discontinuation highlights the need to shift focus from short-term weight loss to long-term behavioral stabilization
She was in pain, developing multiple flare-ups per month, and with no energy
Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food
Although the findings are encouraging, scientists say larger studies are needed before concluding that the medication can help people age more slowly