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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

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SOCS genes are translated as a result of cytokine-induced activation as part of the JAKSTAT negative feedback loop

ParkBBakbakETeohHKrishnarajADennisFQuanAet al

This means they are regulated under food supplement legislation (the Food Supplements (England) Regulations 2003 and equivalent devolved legislation) rather than by the Medicines and Healthcare products Regulatory Agency (MHRA) as pharmaceutical products

How is this treated & what is the mechanism