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Preclinical studies confirm that targeting HSP90 effectively ameliorates depressive-like behaviors: quercetin inhibits HSP90 to suppress NLRP3 inflammasome activation and levels of cytokines (IL-6, IL-1, and TNF-), alleviating hippocampal neuroinflammation [30]

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These results suggest that NTAPP may affect cellular response via the canonical Wnt/-catenin signaling pathway by stimulating secretion of Wnt ligands in hDP cells

FrancqueSMMarchesiniGKautzAWalmsleyMDornerRLazarusJVet al

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