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At one point I was up to 800 micrograms of Metfolin a day and tolerating it only by adding slowly 200 micrograms per day and when my NutrEval indicated I needed 1200 micrograms per day of Metfolin and I tried to go up, felt fullness in my chest, shakes, irritable and as if I might get a migraine

Loading doses may be a good fit for people who: Are trying NAD+ therapy for the first time and want a stronger initial foundation Feel persistently depleted, run down, or slow to recover from stress and exertion Are navigating high-demand seasons (such as burnout, intense workloads, travel, or poor sleep) Want more reinforcement for energy, resilience, and cellular function Are experiencing higher immune-related stress, including those with autoimmune-related concerns How NAD+ IV Therapy Fits Into a Longevity-Focused Wellness Routine NAD+ therapy is often discussed in isolation, but it works best when viewed as part of a broader, longevity-focused wellness approach

However, these are typically associated with long-term mega-doses far exceeding whats in your weekly shot

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