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doi: 10.3389/fcell.2025.1529901 Received 18 November 2024 Accepted 08 January 2025 Published 22 January 2025 Volume 13 - 2025 Edited by Yan Chun Li, The University of Chicago, United States Reviewed by Asuncion Romero-Molina, Consultant, Barcelona, Spain Vishwadeep Shelke, Tulane University, United States Updates Copyright 2025 Cheng, Wang, Ma and Zhou

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A key difference between the two drugs is that Zepbound is a dual receptor agonist that works on both GLP-1 and gastric inhibitory polypeptide (GIP)

Nuclear factor erythroid-2-related factor (NRF2) is implicated in the biosynthesis of GSH [99,100,101] and protection from oxidative stress and tissue damage [101]