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Injured fibroblasts and keratinocytes release cytokines, growth factors, and peptide signals essentially a biological distress call that instruct surrounding cells to upregulate collagen production, promote angiogenesis (new blood vessel formation), and begin remodeling the extracellular matrix

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The effect was practical and immediate: licensed compounding pharmacies could no longer prepare injectable GHK-Cu, pushing demand toward gray-market sources with zero quality control