However, there is one major difference that separates retatrutide from tirzepatide: retatrutide targets three hormone receptors, while tirzepatide targets two
GLP-1: Key to Metabolic Health GLP-1 is a hormone produced in the small intestine that helps regulate key metabolic functions, such as stimulating insulin release, suppressing glucagon, and promoting satiety
doi: 10.1016/j.neuropharm.2016.07.039
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
Angarita Dvila L, et al
GLP-1-RA such as liraglutide [4], semaglutide [5], and the dual agonist tirzepatide [6], activating both the GLP1- and the gastric-inhibitory polypeptide receptor (GIP-R), have been shown to significantly reduce body weight, making them a promising therapeutic option for the treatment of obesity