The key epidemiological and clinical studies on chronic constipation-depression comorbidity are summarized in Table 2
Potentiation of ACh release through transcutaneous vagal neuromodulation is known to enhance gut motility, reduce inflammation by suppressing TNF- , and preserve epithelial tight junction integrity through the activation of enteric glial cells (243)
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Common side effects of Mounjaro include gastrointestinal symptoms, similar to Saxenda and Wegovy
Nat Rev Mol Cell Biol 23(7):499515
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