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Other risk factors that may increase vulnerability include: Long duration of diabetes (typically more than 10 years) Poor glycaemic control prior to starting GLP-1 therapy (HbA1c significantly above target) Rapid reduction in HbA1c (a drop of more than 2 percentage points [22 mmol/mol] within 36 months) Concurrent hypertension , especially if poorly controlled Diabetic kidney disease (nephropathy), which often correlates with retinopathy severity Previous history of retinal treatment (laser photocoagulation or intravitreal injections) People with type 2 diabetes but no retinopathy appear to have minimal risk of retinopathy progression based on current evidence

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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Martin-Murphy BV, Holt MP, Ju C.The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice

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NMN is an abbreviation for "-nicotinamide mononucleotide"