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The impact of GM on drugs used in management of cardiac arrhythmia Anti-arrhythmic drugs (AAD) are grouped in the Vaughan Williams classification into 4 groups according to the ion channel or receptor they exert their anti-arrhythmic effect on
(See the list of studies, linked here.) The EPIC trial's report concluded: "Chronic oral administration of pimobendan to dogs with echocardiographic and radiographic evidence of cardiomegaly [enlargement] secondary to MMVD, in the absence of concurrent cardiovascular medication, results in the prolongation of the preclinical period, and is safe and well tolerated." Note that, as big a step as the EPIC trial took for promoting pimobendan, its investigators still emphasized the necessity of both "echocardiographic and radiographic [x-ray] evidence" that the dog's heart is enlarged due to MVD
This article walks you through why that is, how each ingredient works, key safety signals, a sensible way to try the stack if you choose to do so, and what to monitor over time
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