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injections of 100 nmol kg 1 MK-801 ( n = 7-8 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice) or vehicle (isotonic saline, n = 8 mice) for 14 days

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The primary endpoint was the percentage change in body weight from baseline to week 72

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A small fraction of people with obesity carry rare, single-gene mutations that cause what is known as monogenic obesity, which leads to health issues at an early age

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