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Peer review Peer review information Nature Communications thanks the anonymous, reviewers for their contribution to the peer review of this work

As mentioned above, oxidative stress is the main secondary injury in TBI caused by iron overload

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

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Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS): To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy (REMS) for these products