It also plays a role in the gene expression of natural detoxification enzymes in the brain, including glutathione S-transferase offering important brain antioxidant protection, contributing to better cognitive health and memory
It focuses on neutralizing oxidative stress, supporting the liver, and protecting cells from environmental damage
We were stunned to find out that estradiol and testosterone affect (activate or inhibit) 5 major enzymes in OCM: SHMT, MTHFR, MS, BHMT, and PEMT (full names of the enzymes can be found below in our paper
Min et al., 2015)
Some previous experimental and cross-sectional studies revealed an association between NAFLD and hyperhomocysteinemia 19,20,21,22
Critically, UGT inhibition (not substrate activity) correlates with hepatotoxic potential.A drugs inhibition of UGT enzymes is a direct indicator of increased hepatotoxicity risk