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This peptide sequence is crucial for the angiogenic and wound healing properties of thymosin beta-4, contributing to the formation of new blood vessels and the repair of damaged tissues

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Mechanistically, PA disrupts intracellular iron homeostasis via ER calcium release, upregulates transferrin (TF)-mediated iron transport, and ultimately triggers ferroptotic death through iron overload ( 2.4 Induction of cell cycle arrest Cell cycle arrest, achieved by downregulating cyclins and cyclin-dependent kinases (CDKs), represents a key anti-cancer strategy