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For the repair peptides, mostly not
Once you settle in at your maintenance dose, gastrointestinal side effects should improve and ultimately go away (although for some people, you may feel mild side effects the day after you give yourself the injection)
The latter is greatly influenced by hepatic blood flow, which might not be constant (45) and could have been improved, in our study, by the vasodilatory effects of L-ARG and NAC, which improve hepatic metabolic dynamics
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Because the two peptides have different half-lives, combined protocols described in the literature typically reflect their different dosing frequencies