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For all included studies, the intervention (retatrutide or LY3437943) was administered subcutaneously once weekly in multiple ascending doses, except in one single-dose pharmacokinetic study

To date, two HDACs have been implicated in erythropoiesis: HDAC5 [84] and HDAC2 [87]

Prescribers will play a critical role in minimizing the downsides of GLP-1 RA therapy by considering AE risk into patient selection, providing updated information to discuss risks and benefits with patients, and proactively monitoring for and addressing potential side effects

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If you cannot use retatrutide, or you need a different option, these FDA-approved drugs are safe and good

The microdose approach represents a clinically sound starting strategy that many patients prefer before advancing to standard therapeutic concentrations