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Jacob, M., Chappell, D

Skin whitening typically involves using products that reduce pigmentation, such as vitamin C, or skin-brightening agents like glutathione and niacinamide

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A larger number remain investigational compounds supported by limited clinical data

In terms of intervention, aerobic exercise upregulates LONP1 and mitochondrial-encoded genes in aged mouse skeletal muscle, ameliorating mitochondrialnuclear signaling imbalance and activating the UPRmt, indicating that exercise may improve muscle dysfunction in aging or pathological states by enhancing LONP1 expression or activity [136]

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