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A smaller percentage of patients benefit from combination therapy, such as pairing semaglutide with a second compound like tirzepatide, which activates both GLP-1 and GIP receptors for synergistic effects

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Many people notice that foods they previously enjoyed, particularly high-sugar and high-fat options, become less appealing

JAMA Psychiatry 70 , 619629 (2013)

Its a catastrophic point of failure