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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial

Gladman DD, Ang M, Su L, Tom BDM, Schentag CT, Farewell VT

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Diabetes 60(12):31033109 Yanagimachi T, Fujita Y, Takeda Y et al (2016) Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (130) expression is upregulated in diabetes and PEGylated GIP(130) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice

As with other GLP-1-based therapies, the most commonly reported side effects of retatrutide in clinical trials are gastrointestinal in nature