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Koe, W.J., Samson, R.A., van Egmond, H.P., Gilbert, J
In particular, Val-Cit and Val-Ala linkers coupled with p -aminobenzyloxycarbonyl (Val-Cit-PABC and Val-Ala-PABC) are the most successful cleavable linkers for ADCs (Dubowchik et al., 2002
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It has shown strong anti-proliferative and anti-metastatic effects in vitro and in vivo and also reduced the production of inflammatory cytokines such as IL-6 and TNF- thus suggesting it to be an important therapeutic agent against cancer progression
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