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In a rat model of autoimmune thyroiditis, TGPL significantly lowered serum TPOAb, TGAb, and TNF- levels while boosting IL-10 levels and ameliorating thyroid follicle damage

The study focused on newly initiated treatments and evaluated outcomes occurring within the first five years after therapy initiation

Using the correct technique (pinching the skin, injecting at 90 degrees, using the recommended needle length) minimises this risk

This is the clinical context that the TRIUMPH program is now validating at scale

Primary Handling Editor: Jerome Staal, in collaboration with the Nature Medicine team

4c), an observation that is in agreement with our biochemical analyses (Table 1)