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The patients who benefit most are those in steep deficits (1,2001,400 calories daily for women, 1,6001,800 for men) who present with elevated liver enzymes or fatigue despite adequate macronutrient intake

No safety data exists for these populations

For acne, lower-dose isotretinoin may be appropriate for patients who: Are highly sensitive to side effects Require prolonged treatment Have difficulty tolerating standard doses For GLP-1 medications, lower dosing within approved ranges may be reasonable if a patient is responding well

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