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In 2023, sales of Mounjaro reached $5.163 billion, a 970% increase, far surpassing the initial performance of semaglutide, which had sales of $286 million in 2018 and $1.686 billion in 2019, a 490% increase

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Instead, doctors may lean towards recommending lifestyle adjustments or medications that have been scientifically proven to effectively treat medical conditions

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See Table 1 for which patient groups should not receive GLP-1 therapy[511,18] Cautions for GLP-1 and GIP therapy use GLP-1 and GIP therapy should be used with caution in certain patient groups

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Cost, accessibility, and safety are important considerations with regenerative modalities

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Frag 176-191 retains only the lipolytic arm with no IGF-1 elevation, eliminating the major class-level side-effect concerns (gigantism, insulin resistance, certain tumor risk signals)

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