Cost is consideration ($1,200-1,400/month projected)
For instance, in one 1960s study of intravenous NAD+ for addiction, patients who received a fast IV drip experienced immediate headache and shortness of breath, whereas those given the same dose at a slower drip rate (under approximately 35 drops/min) had no distress
Schoenenberger (1986) Delta sleep-inducing peptide in spontaneously hypertensive rats Pharmacology Biochemistry and Behavior, Volume 24, Issue 6, June 1986, Pages 1797-1799
Only a small percentage of a standard oral dose is absorbed through this active pathway, and that number drops further when digestion is impaired
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