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However the down side to this increased mitochondrial function was that more oxidative damage occurred (3) , so the researchers decided to add the powerful mitochondrial antioxidant alpha lipoic acid (ALA) to the mix to see if they could get the best of both worlds: increased mitochondrial energy output, with reduced mitochondrial damage

Kumar V, Singh DD, Lakhawat SS, Yasmeen N, Pandey A, Singla RK

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Role of oxygen and its radicals in peripheral nerve regeneration: from hypoxia to physoxia to hyperoxia

Regarding the safety profile of naltrexone-bupropion, our experience was in line with those observed in the COR programme [20]