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Understanding what we know, and what we don't know, about long-term use helps you make informed decisions

The efficacy and safety of topical spironolactone and flutamide are supported by limited data with some conflicting results

Biological roles of CCAAT/enhancer-binding protein during inflammation

Drug interactions refer to changes in the mechanism of a drug due to factors such as foods, drinks, or other drugs

Regular eye examinations may be recommended during long-term use

Confirmation requires capillary blood glucose measurement during symptomatic episodes, ideally demonstrating glucose levels below 3.0 mmol/L with symptom resolution following carbohydrate intake (Whipple's triad)